Esketamine For Depression Here’s How It Works

Patients suffering from treatment-resistant depression no longer have to feel at a loss. There is encouraging news for persons suffering from severe treatment-resistant depression: Esketamine is a revolutionary medicine that can relieve serious depression within hours. Esketamine for depression treatment is a novel innovative medication that alleviates serious depressive illness within hours in some cases. Esketamine is praised as a completely novel medication that has enabled a large number of people to live their lives without the filter of depression.

What Exactly Is Esketamine?

Esketamine is derived from the anesthetic ketamine, which has long been used to treat depression. 

Esketamine is an intranasal medication that works in the brain. It is licensed in combination with an oral antidepressant for treating treatment-resistant depression.

However, it wasn’t until recently that esketamine, a more powerful variant of ketamine, received the U.S. Food and Drug Administration (FDA) permission for use as a nasal spray for those suffering from treatment-resistant depression. 

In addition to esketamine as an alternative depression treatment program, the FDA has approved Transcranial Magnetic Stimulation (TMS) as well in the treatment of specific behavioral health conditions.

How Does Esketamine Therapy Work?

Because esketamine, like ketamine, has the potential to alter perception in the first two hours following treatment, it must be delivered in a clinical environment. 

Under a doctor’s supervision, you administer three doses of nasal spray, five minutes apart. You will be kept at the clinic under the doctor’s supervision until any probable adverse effects have passed.

Esketamine must be used with a standard antidepressant. The goal is for esketamine to offer immediate relief from depressive symptoms until the other medicine takes action.

Who Is Suitable for Esketamine Therapy?

Esketamine is now licensed for treatment-resistant depression. That indicates you’ve taken at least two other antidepressants (for at least six weeks each) and haven’t seen remission or at least a 50% improvement in mood.

How Is Esketamine Used to Treat Depression?

Esketamine and its related medication ketamine are extremely effective depression therapies for a variety of reasons, including:

  • The antidepressant action of ketamine differs from that of other medications. Traditional antidepressants raise levels of naturally occurring neurotransmitters such as norepinephrine, serotonin, and dopamine. These molecules act as messengers, relaying information between brain cells. The hypothesis is that having more of these neurotransmitters allows for better communication between brain cells and hence improves mood.
  • Esketamine functions similarly to other antidepressants, except it raises glutamate levels, the most common chemical messenger in the brain. The end result? A larger influence on more brain cells at the same time.

Are There Any Negative Side Effects of Esketamine?

Esketamine medication can cause a wide range of negative effects in patients. Hallucinations and feeling estranged from yourself or reality are the most dramatic. However, adverse effects often peak at 40 minutes and fade after two hours of therapy.

The first two treatments will have the most severe adverse effects. After then, symptoms normally subside. Other possible adverse effects include:

  • Blood pressure rise
  • Nausea 
  • Feeling tipsy
  • Drowsiness
  • Headache

If you think that your current depression treatment is not working for you, you may want to consult with Wonder Years to explore if depression treatment SPRAVATO® (esketamine) is the right choice for you.

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ADHD And Depression: Are They Related?

It is common for attention deficit hyperactivity disorder (ADHD) and depression to co-exist in an individual. Also known as comorbidity, one can experience a combination of symptoms from ADHD and depression at the same time. ADHD is a brain disorder that affects both children and adults and makes it difficult for them to keep their focus. Depression is the persistent feeling of deep sadness or emptiness that lasts at least 2 weeks, making daily functioning a challenge. Read on to find out more about how ADHD and depression are related and treated.

The Relationship Between ADHD and Depression

As mentioned above, ADHD and depression may share many symptoms, and this makes it harder to diagnose and treat them. One example is the inability to focus on tasks, which is associated with both ADHD and depression. Medications that help to treat ADHD may result in side effects pertaining to appetite and sleep, which may also look like symptoms of depression. Moreover, children who are hyperactive or easily irritable could have either ADHD or depression.

ADHD patients are more susceptible to developing depression, especially if they are experiencing difficulties in coping with their ADHD. Children who are unable to get along with schoolmates or adults who have trouble relating to colleagues can lead to social isolation and feelings of dejectedness and hopelessness – signs of depression. 

Whilst professionals are often unsure of the exact cause of ADHD or depression, there is evidence linking both conditions to family history. Individuals with ADHD or depression usually have another family member with the condition. 

ADHD and Depression Diagnosis and Treatments

If you suspect that you or a loved one is suffering from ADHD, depression, or both, the first step is to take it up with your GP PCP. Whilst they are unable to provide a diagnosis, they can refer the patient to a psychiatrist or other health care provider with the qualifications to perform a neuropsychological assessment.

The health care specialist would likely conduct a physical examination to rule out any physical conditions, as well as an interview to evaluate the severity of the symptoms. Because ADHD and depression comorbidity are difficult to diagnose, some patients may benefit from having a second opinion. 

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